MUSCLE REGENERATION & REGENERATIVE MEDICINE
THREE-DIMENSIONAL CHROMATIN RE-ORGANIZATION DURING MUSCLE STEM CELL AGING
Benjamin A. Yang, Jacqueline A. Larouche, Kaitlyn M. Sabin, Paula M. Fraczek, Stephen C. J. Parker, Carlos A. Aguilar. Aging Cell. e13789 (2023). Link to Data.
MARESIN 1 REPLETION IMPROVES MUSCLE REGENERATION AFTER VOLUMETRIC MUSCLE LOSS
Jesus A. Castor-Macias, Jacqueline A. Larouche, Emily C. Wallace, Bonnie D. Spence, Alec Eames, Benjamin A. Yang, Carol Davis, Susan V. Brooks, Krishna Rao Maddipati, James F. Markworth, Carlos A. Aguilar. eLife 12, e86437 (2023). Link to Code. Link to Data. Press
SPATIOTEMPORAL MAPPING OF IMMUNE AND STEM CELL DYSREGULATION AFTER VOLUMETRIC MUSCLE LOSS
Jacqueline A. Larouche, Emily C. Wallace, Bonnie D. Spence, Eric Buras, Carlos A. Aguilar. JCI Insight. 8:7 e162835 (2023). Link to Code. Link to Data
NEUTROPHIL AND NATURAL KILLER CELL IMBALANCES PREVENT MUSCLE STEM CELL MEDIATED REGENERATION FOLLOWING MURINE VOLUMETRIC MUSCLE LOSS
Jacqueline A. Larouche, Paula M. Fraczek, Sarah J. Kurpiers, Benjamin A. Yang, Carol Davis, Jesus A. Castor-Macias, Kaitlyn Sabin, Shannon Anderson, Julia Harrer, Matthew Hall, Susan V. Brooks, Young C. Jang, Nick Willett, Lonnie D. Shea, Carlos A. Aguilar. Proc. Nat'l. Acad. Sci. USA, 119 (15) e2111445119 (2022). Link to Code. Link to Data. Press.
SESTRINS REGULATE MUSCLE STEM CELL METABOLIC HOMEOSTASIS
Benjamin A. Yang, Jesus Castor-Macias, Paula Fraczek, Ashley Cornett, Lemuel A. Brown, Myungjin Kim, Susan V. Brooks, Isabelle M.A. Lombaert, Jun Hee Lee, Carlos A. Aguilar. Stem Cell Reports, Vol. 16, Issue 9, 2078-2088 (2021). Link to Data.
MURINE MUSCLE STEM CELL RESPONSE TO PERTURBATIONS OF THE NEUROMUSCULAR JUNCTION ARE ATTENUATED WITH AGING
Jacqueline A. Larouche, Mahir Mohiuddin, Jeongmoon J Choi, Peter J Ulintz, Paula M Fraczek, Kaitlyn Sabin, Sethuramasundaram Pitchiaya, Sarah J Kurpiers, Jesus Castor-Macias, Wenxuan Liu, Robert Louis Hastings, Lemuel A Brown, James F Markworth, Kanishka De Silva, Benjamin D Levi, Sofia D Merajver, Gregorio Valdez, Joe V Chakkalakal, Young Jang, Susan Brooks, Carlos A Aguilar. eLife, Volume 10, e66749 (2021). Link to Code. Link to Data.
METABOLIPIDOMIC PROFILING REVEALS AN AGE- RELATED DEFICIENCY
OF SKELETAL MUSCLE PRO- RESOLVING MEDIATORS THAT CONTRIBUTES TO
MALADAPTIVE TISSUE REMODELING
James F. Markworth, Lemuel A. Brown, Eunice Lim, Jesus A. Castor-Macias, Jacqueline Larouche, Peter C. D. Macpherson, Carol Davis, Carlos A. Aguilar, Krishna Rao Maddipati, Susan V. Brooks. Aging Cell, Vol. 20, Issue 6, e13393 (2021).
ENGINEERED TOOLS TO STUDY INTERCELLULAR COMMUNICATION
Benjamin A. Yang, Trisha M. Westerhof, Kaitlyn Sabin, Sofia D. Merajver, Carlos A. Aguilar. Advanced Science, Vol. 8, Issue 3, 2002825 (2021).
REPROGRAMMING TO HELP THE OLD SEE LIKE THE YOUNG
Carlos A. Aguilar Science Translational Medicine Vol. 12, Issue 574, eabf7738 (2020).
RESOLVIN D1 SUPPORTS SKELETAL MYOFIBER REGENERATION VIA ACTIONS ON MYELOID AND MUSCLE STEM CELLS
James F Markworth, Lemuel A Brown, Eunice Lim, Carolyn Floyd, Jacqueline Larouche, Jesus A Castor-Macias, Kristoffer B Sugg, Dylan C Sarver, Peter C D Macpherson, Carol S Davis, Carlos A Aguilar, Krishna Rao Maddipati, Susan V Brooks. JCI Insight, Vol. 5, Issue 18, 137713 (2020).
CELLULAR SENOLYTICS
Carlos A. Aguilar. Science Translational Medicine 12 (550), eabd3075 (2020).
DISSECTING MURINE MUSCLE STEM CELL AGING THROUGH INTEGRATIVE GENOMIC ANALYSIS
Anna Shcherbina, Jacqueline Larouche, Benjamin A Yang, Lemuel A Brown, James F Markworth, Carolina Chung, Mehwish Khaliq, Kanishka de Silva, Jeongmoon J Choi, Mohammad F Sichani, Sriram Chandrasekaran, Young C Jang, Susan V Brooks, Carlos A. Aguilar. Cell Reports, Volume 32, Issue 4, 107964 (2020). Press. Link to Data
PRE-INNERVATED TISSUE ENGINEERED MUSCLE PROMOTES A PRO-REGENERATIVE MICROENVIRONMENT FOLLOWING VOLUMETRIC MUSCLE LOSS
Suradip Das, Kevin D. Browne, Franco A Laimo, Joseph C Maggiore, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S Ali, Foteini Mourkioti, D. Kacy Cullen. Nature Communications Biology 3, 330 (2020).
RUNNING MAKES OLD STEM CELLS ACT YOUNG
Carlos A. Aguilar. Science Translational Medicine 12 (542), eabb7092 (2020).
REGENERATING MOTOR NEURONS PRIME MUSCLE STEM CELLS FOR MYOGENESIS BY ENHANCING PROTEIN SYNTHESIS AND MITOCHONDRIAL BIOENERGETICS
Jeongmoon J. Choi, Eun Jung Shin, Woojin M. Han, Shannon E. Anderson, Mahir Mohiuddin, Nan Hee Lee, Thu Tran, Shadi Nakhai, Hyeonsoo Jeong, Anna Shcherbina, Gunjae Jeong, Dong Gun Oh, Laura D. Weinstock, Sitara B. Sankar, Molly E. Ogle, Lida Katsimpardi, Tata Nageswara Rao, Levi Wood, Carlos A. Aguilar, Amy J. Wagers, Young C. Jang. Biorxiv, (2020).
HEMATOPOIETIC MALADAPTATION FACILITATES SEPTIC SCREENING
Carlos A. Aguilar. Science Translational Medicine 12 (534), eabb2768 (2020).
TRANSPLANTATION OF MUSCLE STEM CELL MITOCHONDRIA REJUVENATES THE BIOENERGETIC FUNCTION OF DYSTROPHIC MUSCLE
Mahir Mohiuddin, Jeongmoon J. Choi, Nan Hee Lee, Hyeonsoo Jeong, Shannon E. Anderson, Woojin M. Han, Berna Aliya, Tsvetomira Z. Peykova, Sumit Verma, Andrés J. García, Carlos A. Aguilar, Young C. Jang. Biorxiv, (2020).
TUNING MACROPHAGE PHENOTYPE TO MITIGATE SKELETAL MUSCLE FIBROSIS
David M. Stepien, Charles Hwang, Simone Marini, Chase A. Pagani, Michael Sorkin, Noelle D. Visser, Amanda K. Huber, Nicole J. Edwards, Shawn J. Loder, Kaetlin Vasquez, Carlos A. Aguilar, Ravi Kumar, Shamik Mascharak, Michael T. Longaker, Jun Li, Benjamin Levi. Journal of Immunology, 204 (8), 2203-2215 (2020).
NEW TECHNOLOGIES TO ENHANCE IN VIVO REPROGRAMMING FOR REGENERATIVE MEDICINE
Jacqueline Larouche, Carlos A Aguilar.
Trends in Biotechnology. 37:6, 604-617 (2019).
ROBUST INFLAMMATORY AND FIBROTIC SIGNALING FOLLOWING VOLUMETRIC MUSCLE LOSS: A BARRIER TO MUSCLE REGENERATION
Jacqueline Larouche, Sarah M. Greising, Benjamin T. Corona, Carlos A. Aguilar,. Cell Death Disease, 9: 409 (2018).
MULTISCALE ANALYSIS OF A REGENERATIVE THERAPY FOR TREATMENT OF VOLUMETRIC MUSCLE LOSS INJURY
Carlos A. Aguilar, Sarah M. Greising, Alain Watts, Stephen M. Goldman, Chelsea Peragallo, Christina Zook, Jacqueline Larouche, Benjamin T. Corona. Cell Death Discovery, 4: 33 (2018). Link to data (This paper was listed as best of 2018 and 2019 by the journal).
UNWAVERING PATHOBIOLOGY OF VOLUMETRIC MUSCLE LOSS INJURY
Sarah M. Greising, Jessica C. Rivera, Stephen M. Goldman, Alain Watts, Carlos A. Aguilar, Benjamin T. Corona. Scientific Reports. 7: 13179 (2017). Link to data
RNA TRANSCRIPT EXPRESSION OF IGF-1:PI3K PATHWAY COMPONENTS IN REGENERATING SKELETAL MUSCLE IS SENSITIVE TO INITIAL INJURY INTENSITY
Ronald W. Matheny Jr., Christopher T. Carrigan, Mary N. Abdalla, Alyssa V. Geddis, Luis A. Leandry, Carlos A. Aguilar, Stuart S. Hobbs, Maria L. Urso. Growth Hormone & IGF Research, Vol. 32, Pages 14-21 (2017).
TRANSCRIPTIONAL AND CHROMATIN DYNAMICS OF MUSCLE REGENERATION AFTER SEVERE TRAUMA
Carlos A. Aguilar, Ramona Pop, Anna Shcherbina, Alain Watts, Ronald W. Matheny Jr., Davide Cacchiarelli,Woojin M. Han, Eunjung Shin, Shadi A. Nakhai, Young C. Jang, Christopher T. Carrigan, Casey A. Gifford, Melissa A. Kottke, Marcella Cesana, Maria L. Urso, Alexander Meissner. Stem Cell Reports, Volume 7, Issue 5, Pages 983–997 (2016). Link to Data. F1000 Recommendation.
IN VIVO MONITORING OF TRANSCRIPTIONAL DYNAMICS AFTER LOWER-LIMB MUSCLE INJURY ENABLES QUANTITATIVE CLASSIFICATION OF HEALING
Carlos A. Aguilar, Anna Shcherbina, Darrell O. Ricke, Ramona Pop, Christopher T. Carrigan, Casey A. Gifford, Maria L. Urso, Melissa A. Kottke, Alexander Meissner. Scientific Reports. 5:13885 (2015). Link to Data
BIO & NANOMATERIALS
TRACKING OF NASCENT MATRIX DEPOSITION DURING MUSCLE STEM CELL ACTIVATION ACROSS LIFESPAN USING ENGINEERED HYDROGELS
Pamela Duran, Benjamin A. Yang, Eleanor Plaster,Madeline Eiken, Claudia Loebel, Carlos A. Aguilar. Advanced Biology 2400091 (2024). Link to Data
PRE-INNERVATED TISSUE ENGINEERED MUSCLE PROMOTES A PRO-REGENERATIVE MICROENVIRONMENT FOLLOWING VOLUMETRIC MUSCLE LOSS
Suradip Das, Kevin D. Browne, Franco A Laimo, Joseph C Maggiore, Halimulati Kaisaier, Carlos A. Aguilar, Zarina S Ali, Foteini Mourkioti, D. Kacy Cullen. Nature Communications Biology 3, 330 (2020).
NEW TECHNOLOGIES TO ENHANCE IN VIVO REPROGRAMMING FOR REGENERATIVE MEDICINE
Jacqueline Larouche, Carlos A Aguilar. Trends in Biotechnology. 37:6, 604-617 (2019).
UNWAVERING PATHOBIOLOGY OF VOLUMETRIC MUSCLE LOSS INJURY
Sarah M. Greising, Jessica C. Rivera, Stephen M. Goldman, Alain Watts, Carlos A. Aguilar, Benjamin T. Corona. Scientific Reports. 7: 13179 (2017). Link to data
PROBING ELECTRONIC PROPERTIES OF MOLECULAR ENGINEERED ZINC OXIDE NANOWIRES WITH PHOTOELECTRON SPECTROSCOPY
Carlos A. Aguilar, Richard Haight, Anastassios Mavrokefalos, Brian A. Korgel, Shaochen Chen. ACS Nano, Volume 3, Issue 10, Pages 3057-3062 (2009).
DIRECT MICRO-PATTERNING OF BIODEGRADABLE POLYMERS USING ULTRAVIOLET AND FEMTOSECOND LASERS
Carlos A. Aguilar, Yi Lu, Samuel Mao, Shaochen Chen. Biomaterials, Volume 26, Issue 36, Pages 7642–7649 (2005).
MICRO/NANOFLUIDIC DEVICES
CELLULAR MECHANO-TRANSDUCTION OF HUMAN OSTEOBLASTS IN MICROGRAVITY
Nadab H. Wubshet, Grace Cai, Samuel J. Chen, Molly Sullivan, Mark Reeves, David Mays, Morgan Harrison, Paul Varnado, Benjamin Yang, Esmeralda Arreguin-Martinez, Yunjia Qu, Shan-Shan Lin, Pamela Duran, Carlos A. Aguilar, Shelby Giza, Twyman Clements, Allen P. Liu. npj Microgravity. 10, 35 (2024).
MANIPULATION OF THE NUCLEO-SCAFFOLD POTENTIATES CELLULAR REPROGRAMMING KINETICS
Benjamin A. Yang, André Monteiro da Rocha, Isabel Newton, Anna Shcherbina, Sing-Wan Wong, Paula Fraczek, Jacqueline Larouche, Harrison Hiraki, Brendon M. Baker, Jae-Won Shin, Shuichi Takayama, M. D. Thouless, Carlos A. Aguilar. Biorxiv (2023).
BLOOD–BRAIN BARRIER RE-MODELING IN AN ORGAN‐ON‐A‐CHIP DEVICE SHOWING Dkk1 TO BE A REGULATOR OF EARLY METASTASIS
Trisha M Westerhof, Benjamin A Yang, Nathan M Merill, Joel A Yates, Megan Altemus, Liam Russell, Anna J Miller, Liwei Bao, Zhifen Wu, Peter J Ulintz, Carlos A Aguilar, Aki Morikawa, Maria G Castro, Sofia D Merajver, Christopher R Oliver. Advanced NanoBioMed Research, 2200036 (2023).
DIRECT ANALYSIS OF GENE SYNTHESIS REACTIONS USING SOLID-STATE NANOPORES
Spencer Carson, Scott T. Wick, Peter A. Carr, Meni Wanunu, Carlos A. Aguilar. ACS Nano, Volume 9, Issue 12, Pages 12417–12424 (2015).
MICRO- AND NANOSCALE DEVICES FOR THE INVESTIGATION OF EPIGENETICS AND CHROMATIN DYNAMICS
Carlos A. Aguilar, Harold G. Craighead. Nature Nanotechnology, Volume 8, Pages 709-718 (2013).
INTEGRATION OF SOLID-STATE NANOPORES IN MICROFLUIDIC NETWORKS VIA TRANSFER PRINTING OF SUSPENDED MEMBRANES
Tarun Jain, Ricardo Jose S. Guerrero, Carlos A. Aguilar, Rohit Karnik. Analytical Chemistry, Volume 85, Pages 3871−3878 (2013).
ENHANCED DISCRIMINATION OF DNA MOLECULES IN NANOFLUIDIC CHANNELS THROUGH MULTIPLE MEASUREMENTS
Yi-Heng Sen, Tarun Jain, Carlos A. Aguilar, Rohit Karnik. Lab on a Chip, Volume 12, Pages 1094–1101 (2012).